Aging and Angiogenesis 1200 Pre - Angiogenic Induction 1

1. Abstract 2. Introduction 3. Models for the study of aging and angiogenesis 4. Pathogenesis of impaired angiogenesis in aging 4.1. The microvasculature in aging 4.2. Pre-angiogenic vascular function 4.2.1. Vasodilation: Pre-angiogenic supply-demand vascular compensation 4.2.2. Hemostatic proteolytic cascades: Pre-angiogenic vascular self-defense 4.3. Growth factors in aging 4.3.1. Vascular endothelial growth factor 4.3.2. Platelet-derived growth factor 4.3.3. Fibroblast growth factor 4.4. Aging and impaired growth factor-responses 4.5. The matrix and angiogenesis in aging 4.5.1. Structural matrix proteins 4.5.2. Matricellular proteins 4.5.3. Matrix metalloproteinases 5. Clinical consequences of impaired angiogenesis in aging 5.1. Cardiovascular disease 5.2. Wound healing 5.3. Cancer 6. Future therapies for impaired angiogenesis in aging 7. References